Publications

DOI: 10.1101/2020.06.15.152546

Fluorescence miniature microscopy in vivo has recently proven a major advance, enabling cellular imaging in freely behaving animals. However, fluorescence imaging suffers from autofluorescence, phototoxicity, photobleaching and non-homogeneous illumination artifacts.

Nature Methods

DOI: 10.1038/s41592-020-0835-7

We report jYCaMP1, a yellow variant of the calcium indicator jGCaMP7 that outperforms its parent in mice and flies at excitation wavelengths above 1,000 nm and enables improved two-color calcium imaging with red fluorescent protein-based indicators.

DOI: 10.1101/2020.04.21.044982

Here, we perform a theoretical study of the depth limits of bioluminescence microscopy and find that cellular resolution imaging should be possible at a depth of 5-10 mean free paths.

Optics Express

DOI: 10.1364/oe.378460

We explore the potential for the spatial frequency modulated imaging method when a spatial light modulator is used to program the excitation source, opening the door to a more versatile, random access imaging environment.

International Journal of Optomechatronics

DOI: 10.1080/15599612.2019.1694610

Here, we demonstrate spatial frequency modulated imaging with enhanced resolution in multiple dimensions for the first time. This is achieved by incorporating multiple linear extended excitation sources oriented with axes at arbitrary angles with respect to each other.