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A three-dimensional musculoskeletal model of the dog
Scientific Reports
DOI: 10.1038/s41598-021-90058-0
We describe here the methods we used to create a detailed musculoskeletal model with 84 degrees of freedom and 134 muscles. Our model has three key-features: three-dimensionality, scalability, and modularity.
Cortical response to naturalistic stimuli is largely predictable with deep neural networks
Science Advances
DOI: 10.1126/sciadv.abe7547
Naturalistic stimuli, such as movies, activate a substantial portion of the human brain, invoking a response shared across individuals. Encoding models that predict neural responses to arbitrary stimuli can be very useful for studying brain function.
3D Printing Hydrogel-Based Soft and Biohybrid Actuators: A Mini-Review on Fabrication Techniques, Applications, and Challenges
Frontiers in Robotics and AI
DOI: 10.3389/frobt.2021.673533
This mini-review surveys existing research efforts to inspire the development of novel fabrication techniques using hydrogel building blocks and identify potential future directions. In this article, existing 3D fabrication techniques for hydrogel actuators are first examined.
Multicolor three-photon fluorescence imaging with single-wavelength excitation deep in mouse brain
Science Advances
DOI: 10.1126/sciadv.abf3531
We report a new three-photon excitation scheme: excitation to a higher-energy electronic excited state, enabling multicolor three-photon fluorescence imaging with deep-tissue penetration in the living mouse brain using single-wavelength excitation.
Improving laser standards for three-photon microscopy
Neurophotonics
DOI: 10.1117/1.nph.8.1.015009
Three-photon excitation microscopy has double-to-triple the penetration depth in biological tissue over two-photon imaging and thus has the potential to revolutionize the visualization of biological processes in vivo. However, three-photon microscopy presents new technological challenges.
Selective postnatal excitation of neocortical pyramidal neurons results in distinctive behavioral and circuit deficits in adulthood
iScience
DOI: 10.1016/j.isci.2021.102157
In genetic and pharmacological models of neurodevelopmental disorders, and human data, neural activity is altered within the developing neocortical network. This commonality begs the question of whether early enhancement in excitation might be a common driver of characteristic behaviors.
The Effects of Mechanical Scale on Neural Control and the Regulation of Joint Stability
International Journal of Molecular Sciences
DOI: 10.3390/ijms22042018
Recent work has demonstrated how the size of an animal can affect neural control strategies. We extend that work to consider effects of mechanical scaling on the maintenance of joint integrity.
Slowly activating outward membrane currents generate input-output sub-harmonic cross frequency coupling in neurons
Journal of Theoretical Biology
DOI: 10.1016/j.jtbi.2020.110509
The objective of this simulation study was to evaluate and quantify the effect of slowly activating outward membrane current, on the non-linearity in the output of a one-compartment Hodgkin-Huxley styled neuron.
The genie in the bottle-magnified calcium signaling in dorsolateral prefrontal cortex
Molecular Psychiatry
DOI: 10.1038/s41380-020-00973-3
This review proposes that the special molecular mechanisms needed for higher cognitive operations confer vulnerability to dysfunction, atrophy, and neurodegeneration when regulation is lost due to genetic and/or environmental insults.